Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002194)
Formula
SVG example
Reactant Propranolol hydrochloride Product 1-Naphthol
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002195 Propranolol hydrochloride 4'-hydroxypropanolol Oxidation - 4-Hydroxylation Propranolol hydrochloride [1], [2]
MR002196 Propranolol hydrochloride Alpha-Naphthoxylactic Acid Oxidation - Oxidation Propranolol hydrochloride [3]
MR002192 Propranolol hydrochloride N-desisopropylpropranolol Oxidation - N-Desisopropylation Propranolol hydrochloride [2]
MR002193 Propranolol hydrochloride Propranolol glucuronide Conjugation - O-Glucuronidation Propranolol hydrochloride [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011747 INX-189 1-Naphthol Unclear - Unclear INX-189 [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011748 1-Naphthol INX-09056 Unclear - Unclear INX-189 [4]
MR011749 1-Naphthol INX-09077 Unclear - Unclear INX-189 [4]
References
1 Isolation, purification, and structure identification of glucuronic acid conjugates of propranolol and alprenolol and their ring-hydroxylated metabolites Drug Metab Dispos. 1984 Nov-Dec;12(6):749-54.
2 Rapid and simultaneous extraction of propranolol, its neutral and basic metabolites from plasma and assay by high-performance liquid chromatography J Chromatogr. 1985 Oct 11;343(2):349-58. doi: 10.1016/s0378-4347(00)84603-4.
3 Propranolol metabolism in normal subjects: association with sex steroid hormones Clin Pharmacol Ther. 1994 Aug;56(2):127-32. doi: 10.1038/clpt.1994.115.
4 In Vitro Metabolite Formation in Human Hepatocytes and Cardiomyocytes and Metabolism and Tissue Distribution in Monkeys of the 2'-C-Methylguanosine Prodrug BMS-986094 : Potential Role in Clinical Cardiovascular Toxicity

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