Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002206)
Formula Reactant Quetiapine fumarate Product O-desalkylquetiapine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Oxidation - N-Dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002204 Quetiapine fumarate 7-hydroxyquetiapine Oxidation - Hydroxylation Quetiapine fumarate [1], [2]
MR002203 Quetiapine fumarate N-desalkylquetiapine Unclear Quetiapine fumarate [1], [2]
MR002205 Quetiapine fumarate Quetiapine sulfoxide Oxidation - Sulfoxidation Quetiapine fumarate [1]
References
1 Metabolism of quetiapine by CYP3A4 and CYP3A5 in presence or absence of cytochrome B5. Drug Metab Dispos. 2009 Feb;37(2):254-8.
2 Metabolism of the active metabolite of quetiapine, N-desalkylquetiapine in vitro. Drug Metab Dispos. 2012 Sep;40(9):1778-84.

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