Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002229)
Formula
SVG example
Degradation
Reactant Selenocystein Product Pyruvate
Reactant Info Product Info
Metabolic Enzyme Selenocysteine lyase (SCLY) DME Info
Metabolic Type Oxidation - Degradation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002227 Selenide Selenocystein Reduction - Reduction Selenium [1], [2], [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002232 Selenocystein Ammonia Oxidation - Degradation Selenium [1]
MR002231 Selenocystein Methyl-selenol Oxidation - Degradation Selenium [1], [4], [5]
MR002230 Selenocystein Selenocysteine selenoxidel Oxidation - Oxidation Selenium [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007375 BRN-4179169 Pyruvate Unclear BRN-4179169 [6]
MR006275 D-glucose Pyruvate Unclear D-glucose [7]
MR003906 E-920 Pyruvate Unclear E-920 [8]
MR004263 Methylglyoxal Pyruvate Unclear Methylglyoxal [9]
MR004433 Oxaloacetate Pyruvate Unclear Oxaloacetate [10]
MR007591 Phosphoenolpyruvate Pyruvate Unclear Phosphoenolpyruvate [11]
MR006379 Sialic acid Pyruvate Unclear Sialic acid [12]
MR003901 D-cysteine Pyruvate Unclear E-920 [8]
MR004262 D-lactaldehyde Pyruvate Unclear Methylglyoxal [9]
MR003899 Mercaptopyruvate Pyruvate Unclear E-920 [8]
MR007373 Mercaptopyruvate Pyruvate Unclear BRN-4179169 [6]
MR003693 PEP Pyruvate Unclear L-651582 [13]
MR003893 3-sulfino-pyruvate Pyruvate Unclear E-920 [8]
MR004208 63P PYR Unclear D-xylulose [14]
MR004180 Phosphoenolpyruvate Pyruvate Unclear Dihydroxyacetone [15]
MR004256 D-lactate Pyruvate Unclear Methylglyoxal [9]
MR001544 Malate Pyruvate Unclear L-glutamine [16]
MR002233 Selenocysteine selenoxidel Pyruvate Oxidation - Degradation Selenium [1]
MR014120 PEP Pyruvate Unclear Lactose [17]
MR014124 PEP Pyruvate Unclear Lactose [17]
MR003945 PEP Pyruvate Unclear Lactose [17]
⏷ Show the Full List of MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004434 Pyruvate A-acetolactate Other reaction - #NAME? Oxaloacetate [10]
MR004436 Pyruvate Acetyl-P Unclear Oxaloacetate [10]
MR003694 Pyruvate Lactate Unclear L-651582 [13]
MR007374 Pyruvate Lactate Unclear BRN-4179169 [6]
MR004209 PYR Acetaldehyde Unclear D-xylulose [14]
MR004181 Pyruvate Alanine Unclear Dihydroxyacetone [15]
MR004257 Pyruvate L-lactate Unclear Methylglyoxal [9]
MR014121 Pyruvate Lactate Unclear Lactose [17]
MR014125 Pyruvate Lactate Unclear Lactose [17]
MR003946 Pyruvate Lactate Unclear Lactose [17]
⏷ Show the Full List of MR
References
1 Selenium metabolism, selenoproteins and mechanisms of cancer prevention: complexities with thioredoxin reductase. Carcinogenesis. 1999 Sep;20(9):1657-66.
2 Biochemistry, Antioxidants. 2023 May 1. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 JanC.
3 Enhanced selenocysteine biosynthesis for seleno-methylselenocysteine production in Bacillus subtilis. Appl Microbiol Biotechnol. 2023 May;107(9):2843-2854. doi: 10.1007/s00253-023-12482-8.
4 Antitumor Effects of Selenium. Int J Mol Sci. 2021 Oct 31;22(21):11844. doi: 10.3390/ijms222111844.
5 Exposure to the Methylselenol Precursor Dimethyldiselenide Induces a Reductive Endoplasmic Reticulum Stress in Saccharomyces cerevisiae. Int J Mol Sci. 2021 May 22;22(11):5467. doi: 10.3390/ijms22115467.
6 Non-invasive monitoring of L-2-oxothiazolidine-4-carboxylate metabolism in the rat brain by in vivo 13C magnetic resonance spectroscopy
7 DrugBank(Pharmacology-Metabolism):D-glucose
8 The mercaptopyruvate pathway in cysteine catabolism: a physiologic role and related disease of the multifunctional 3-mercaptopyruvate sulfurtransferase
9 Cells producing their own nemesis: understanding methylglyoxal metabolism
10 Mechanism of citrate metabolism by an oxaloacetate decarboxylase-deficient mutant of Lactococcus lactis IL1403
11 Pyruvate kinase M2: A simple molecule with complex functions
12 Crystal structures and kinetics of N-acetylneuraminate lyase from Fusobacterium nucleatum. Acta Crystallogr F Struct Biol Commun. 2018 Nov 1;74(Pt 11):725-732.
13 Metabolic Mechanisms and a Rational Combinational Application of Carboxyamidotriazole in Fighting Pancreatic Cancer Progression after Chemotherapy
14 Effects of increased transaldolase activity on D-xylulose and D-glucose metabolism in Saccharomyces cerevisiae cell extracts
15 Probing hepatic metabolism of [2-(13)C]dihydroxyacetone in vivo with (1)H-decoupled hyperpolarized (13)C-MR
16 The Emerging Role of l-Glutamine in Cardiovascular Health and Disease Nutrients. 2019 Sep 4;11(9):2092. doi: 10.3390/nu11092092.
17 Lactose metabolism in Streptococcus lactis: studies with a mutant lacking glucokinase and mannose-phosphotransferase activities

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