Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002308)
Formula Reactant hydroxyl-suvorexant Product Suvorexant metabolite M4
Reactant Info Product Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002313 Suvorexant hydroxyl-suvorexant Oxidation - Hydoxylation Suvorexant [1], [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002310 Suvorexant metabolite M4 Suvorexant metabolite M18 Oxidation - Hydoxylation Suvorexant [2], [3]
MR002309 Suvorexant metabolite M4 Suvorexant metabolite M4 glucuronide Conjugation - Glucuronidation Suvorexant [3]
References
1 Suvorexant: a promising, novel treatment for insomnia. Neuropsychiatr Dis Treat. 2016 Feb 25;12:491-5.
2 CYP450-Mediated metabolism of suvorexant and investigation of metabolites in forensic case specimens Forensic Sci Int. 2020 Jul;312:110307. doi: 10.1016/j.forsciint.2020.110307.
3 In vitro and in vivo characterisation of the metabolism and disposition of suvorexant in humans Xenobiotica. 2016 Oct;46(10):882-95. doi: 10.3109/00498254.2015.1129565.

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