Details of the Metabolic Reaction (MR) | INTEDE

General Information of This Metabolic Reaction (MR) (ID: MR002316)
Formula
	Reactant	Suvorexant		Product	Suvorexant metabolite M17
	Reactant	Reactant Info		Product	Product Info

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR002313	Suvorexant	hydroxyl-suvorexant	Oxidation - Hydoxylation	Suvorexant	[1], [2], [3]
MR002315	Suvorexant	Suvorexant metabolite M10a	Oxidation - Hydoxylation	Suvorexant	[2], [3]
MR002314	Suvorexant	Suvorexant metabolite M8	Oxidation - Hydoxylation	Suvorexant	[2], [3]

References
1	Suvorexant: a promising, novel treatment for insomnia. Neuropsychiatr Dis Treat. 2016 Feb 25;12:491-5.
2	CYP450-Mediated metabolism of suvorexant and investigation of metabolites in forensic case specimens Forensic Sci Int. 2020 Jul;312:110307. doi: 10.1016/j.forsciint.2020.110307.
3	In vitro and in vivo characterisation of the metabolism and disposition of suvorexant in humans Xenobiotica. 2016 Oct;46(10):882-95. doi: 10.3109/00498254.2015.1129565.

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