Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002465)
Formula
UGT1A1 ...
SVG example
Glucuronidation
Reactant Troglitazone Product Troglitazone glucuronide metabolite
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
UDP-glucuronosyltransferase 1A10 (UGT1A10) DME Info
UDP-glucuronosyltransferase 1A8 (UGT1A8) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002466 Troglitazone Troglitazone Quinone Oxidation - Oxidation Troglitazone [1], [2]
MR002464 Troglitazone Troglitazone sulfate metabolite Conjugation - Sulfation Troglitazone [3]
References
1 Oxidation of troglitazone to a quinone-type metabolite catalyzed by cytochrome P-450 2C8 and P-450 3A4 in human liver microsomes. Drug Metab Dispos. 1999 Nov;27(11):1260-6.
2 Intestinal motility and its disorders Scand J Urol Nephrol Suppl. 1992;142:18-21.
3 Clinical pharmacokinetics of troglitazone Clin Pharmacokinet. 1999 Aug;37(2):91-104. doi: 10.2165/00003088-199937020-00001.

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