Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002484)
Formula
SVG example
Oxidation
Reactant Valbenazine Product NBI-136110
Reactant Info Product Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002485 Valbenazine [+]alpha-HTBZ Hydrolysis - Hydrolysis Valbenazine [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009235 Ingrezza NBI-136110 Oxidation - Oxidation Ingrezza [1], [3]
References
1 Pharmacologic Characterization of Valbenazine (NBI-98854) and Its Metabolites J Pharmacol Exp Ther. 2017 Jun;361(3):454-461. doi: 10.1124/jpet.116.239160.
2 Pharmacokinetic and Pharmacologic Characterization of the Dihydrotetrabenazine Isomers of Deutetrabenazine and Valbenazine. Clin Pharmacol Drug Dev. 2023 Apr;12(4):447-456. doi: 10.1002/cpdd.1205.
3 VMAT2 Inhibitors in Neuropsychiatric Disorders

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