Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002497)
Formula
UGT1A10 ...
SVG example
Dehydrogenation
Reactant Valproic acid Product Valproic acid beta-O-glucuronide metabolite
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A10 (UGT1A10) DME Info
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
UDP-glucuronosyltransferase 1A3 (UGT1A3) DME Info
UDP-glucuronosyltransferase 1A8 (UGT1A8) DME Info
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
UDP-glucuronosyltransferase 1A6 (UGT1A6) DME Info
UDP-glucuronosyltransferase 1A4 (UGT1A4) DME Info
UDP-glucuronosyltransferase 2B15 (UGT2B15) DME Info
Metabolic Type Oxidation - Dehydrogenation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002499 Valproic acid (3E)-2-Propylpent-3-enoic acid Unclear Valproic acid [1]
MR002498 Valproic acid (3Z)-2-Propylpent-3-enoic acid Oxidation - Dehydrogenation Valproic acid [1]
MR002496 Valproic acid 2-ene-Valproic acid Oxidation - Dehydrogenation Valproic acid [1]
MR002495 Valproic acid 3-hydroxyvalproic acid Unclear Valproic acid [1]
MR002493 Valproic acid 4-ene-Valproic acid Oxidation - 3-Hydroxylation Valproic acid [1]
MR002492 Valproic acid 4-hydroxyvalproic acid Oxidation - 4-Hydroxylation Valproic acid [1]
MR002494 Valproic acid 5-hydroxyvalproic acid Oxidation - 5-Hydroxylation Valproic acid [1]
MR002500 Valproic acid Valproic acid CoA Unclear Valproic acid [2]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 PharmGKB: the Pharmacogenomics Knowledge Base Methods Mol Biol. 2013;1015:311-20. doi: 10.1007/978-1-62703-435-7_20.

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