Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002525)
Formula	DPYS Hydrolysis
	Reactant	FUH2	Product	FUPA
	Reactant	Reactant Info	Product	Product Info
Metabolic Enzyme	Dihydropyrimidinase (DPYS)				DME Info
Metabolic Type	Hydrolysis - Hydrolysis

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Produce The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR002524	5-fluorouracil	FUH2	Reduction - Reduction	Capecitabine	[1]

Other MR(s) Related to The Product of This MR

Other MR(s) That Produce The Product of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR005274	5-FUH2	FUPA	Hydrolysis - Hydrolysis	Tegafur-uracil	[2]

Other MR(s) That Metabolize The Produtc of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR005275	FUPA	FBAL	Hydrolysis - Hydrolysis	Tegafur-uracil	[2]
MR005276	FUPA	Urea	Hydrolysis - Hydrolysis	Tegafur-uracil	[2]
MR002526	FUPA	FBAL	Hydrolysis - Amide Hydrolysis	Capecitabine	[1]

References
1	A new, validated HPLC-MS/MS method for the simultaneous determination of the anti-cancer agent capecitabine and its metabolites: 5'-deoxy-5-fluorocytidine, 5'-deoxy-5-fluorouridine, 5-fluorouracil and 5-fluorodihydrouracil, in human plasma
2	DrugBank(Pharmacology-Metabolism):Tegafur-uracil

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