Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002694)
Formula
SVG example
Reactant 2-hydroxyestrone Product 2-hydroxyestrone-3-methyl
Reactant Info Product Info
Metabolic Enzyme Catechol O-methyltransferase (COMT) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013313 E-3A 2-hydroxyestrone Oxidation - 2-hydroxylation E-3A [1]
MR002696 Estrone 2-hydroxyestrone Oxidation - 2-Hydroxylation Estrone [2]
MR002625 Estradiol 2-hydroxyestrone Oxidation - 2-Hydroxylation Estradiol acetate [3], [4]
MR002648 Estradiol 2-hydroxyestrone Oxidation - Hydroxylation Estradiol cypionate [3], [4]
MR002671 Estradiol 2-hydroxyestrone Oxidation - Hydroxylation Estradiol valerate [3], [4]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013314 2-hydroxyestrone 2-hydroxyestradiol Unclear E-3A [5]
MR002693 2-hydroxyestrone 2-methoxyestrone Unclear Estrone [6]
MR013317 2-hydroxyestrone 2-methoxyestrone Unclear E-3A [4]
MR002641 2-hydroxyestrone 2-hydroxyestradiol Unclear Estradiol acetate [7]
MR002664 2-hydroxyestrone 2-hydroxyestradiol Unclear Estradiol cypionate [7]
MR002687 2-hydroxyestrone 2-hydroxyestradiol Unclear Estradiol valerate [7]
MR002640 2-hydroxyestrone 2-methoxyestrone Unclear Estradiol acetate [4]
MR002663 2-hydroxyestrone 2-methoxyestrone Unclear Estradiol cypionate [4]
MR002686 2-hydroxyestrone 2-methoxyestrone Unclear Estradiol valerate [4]
References
1 DrugBank(Pharmacology-Metabolism)Estradiol acetate
2 Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms. Endocrinology. 2003 Aug;144(8):3382-98.
3 The metabolism of estradiol; oral compared to intravenous administration J Steroid Biochem. 1985 Dec;23(6A):1065-70. doi: 10.1016/0022-4731(85)90068-8.
4 Cytochromes P450: a structure-based summary of biotransformations using representative substrates Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742.
5 DrugBank(Pharmacology-Metabolism):E-3A
6 Evaluation of electrospray ionization and atmospheric pressure chemical ionization for simultaneous detection of estrone and its metabolites using high-performance liquid chromatography/tandem mass spectrometry J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Dec 1;860(1):49-56. doi: 10.1016/j.jchromb.2007.10.014.
7 Cytochrome P450-mediated metabolism of estrogens and its regulation in human Cancer Lett. 2005 Sep 28;227(2):115-24. doi: 10.1016/j.canlet.2004.10.007.

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