Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002826)
Formula Reactant Capsaicin Product Capsaicin glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002818 Capsaicin Capsaicin metabolite M1 Oxidation - Dehydrogenation Capsaicin [1]
MR002819 Capsaicin Capsaicin metabolite M2 Oxidation - Omega-Hydroxylation Capsaicin [1]
MR002820 Capsaicin Capsaicin metabolite M3 Oxidation - Omega-1-Hydroxylation Capsaicin [1]
MR002821 Capsaicin Capsaicin metabolite M4 Oxidation - Dehydrogenation Capsaicin [1]
MR002822 Capsaicin Capsaicin metabolite M5M7 Oxidation - Hydroxylation Capsaicin [1]
MR002823 Capsaicin Capsaicin metabolite M6 Oxidation - O-Dehydrogenation Capsaicin [1]
MR002824 Capsaicin Capsaicin metabolite M8 Oxidation - N-Dehydrogenation; Oxygenation Capsaicin [1]
MR002825 Capsaicin Capsaicin metabolite M9 Oxidation - N-Dehydrogenation Capsaicin [1]
References
1 Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells. Chem Res Toxicol. 2003 Mar;16(3):336-49.

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