Details of the Metabolic Reaction (MR) | INTEDE

General Information of This Metabolic Reaction (MR) (ID: MR002856)
Formula	CYP3A4 Oxidation
	Reactant	Ivacaftor		Product	M6 (ivacaftor-carboxylate)
	Reactant	Reactant Info		Product	Product Info
Metabolic Enzyme	Cytochrome P450 3A4 (CYP3A4)					DME Info
Metabolic Type	Oxidation - Oxidation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR002855	Ivacaftor	M1 (hydroxymethyl-ivacaftor)	Oxidation - Hydroxylation	Ivacaftor	[1], [2]

References
1	PharmGKB summary: ivacaftor pathway, pharmacokinetics/pharmacodynamics Pharmacogenet Genomics. 2017 Jan;27(1):39-42. doi: 10.1097/FPC.0000000000000246.
2	Sensitivity of ivacaftor to drug-drug interactions with rifampin, a cytochrome P450 3A4 inducer. Pediatr Pulmonol. 2018 May;53(5):E6-E8.

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