Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002892)
Formula
SVG example
Reactant Desmethylselegiline Product Levamfetamine
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010843 Selegiline Desmethyl selegiline Unclear - Unclear Selegiline [1]
MR002889 Selegiline hydrochloride Desmethylselegiline Oxidation - N-Dealkylation Selegiline hydrochloride [2], [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010844 Desmethyl selegiline Amphetamine Unclear - Unclear Selegiline [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002891 Levmetamfetamine Levamfetamine Oxidation - N-Dealkylation Selegiline hydrochloride [2]
References
1 Physiologically Based Pharmacokinetic Modeling of Transdermal Selegiline and Its Metabolites for the Evaluation of Disposition Differences between Healthy and Special Populations
2 Comparative studies on the cytochrome p450-associated metabolism and interaction potential of selegiline between human liver-derived in vitro systems. Drug Metab Dispos. 2003 Sep;31(9):1093-102.
3 Detection of l-Methamphetamine and l-Amphetamine as Selegiline Metabolites. J Anal Toxicol. 2021 Feb 6;45(1):99-104. doi: 10.1093/jat/bkaa058.

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