Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002986)
Formula
SVG example
Unclear
Reactant Alitretinoin Product 13-cis-retinoic acid
Reactant Info Product Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002991 Alitretinoin 4-hydroxy-9-cis-retinoic acid Unclear - Unclear Alitretinoin [1]
MR002989 Alitretinoin 4-oxo-13-cis-retinoic acid Unclear - Unclear Alitretinoin [2]
MR002988 Alitretinoin 4-oxo-9-cis-retinoic acid Unclear - Unclear Alitretinoin [1]
MR002990 Alitretinoin 4-oxo-all-trans-retinoic acid Unclear - Unclear Alitretinoin [2]
MR002987 Alitretinoin all-trans-retinoic acid Unclear - Unclear Alitretinoin [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009631 Tretinoin 13-cis RA Other reaction - Isomerization Tretinoin [3], [4]
MR005734 Retinoic acid 13-cis-retinoic acid Unclear Beta carotene [5]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009633 13-cis RA 13-cis-4-Oxoretinoic acid Oxidation - Oxidation Tretinoin [3]
MR009632 13-cis RA 13-cis-Retinoyl-beta-glucuronide Conjugation - Glucuronidation Tretinoin [6], [7]
MR005735 13-cis-retinoic acid 9-cis-retinoic acid Unclear Beta carotene [5]
References
1 DailyMed : Alitretinoin
2 The single-dose pharmacokinetics of alitretinoin and its metabolites are not significantly altered in patients with cirrhosis Br J Dermatol. 2014 Feb;170(2):408-14. doi: 10.1111/bjd.12546.
3 Human cytochrome P450s involved in the metabolism of 9-cis- and 13-cis-retinoic acids
4 Retinoic acid metabolism and mechanism of action: a review
5 #NAME?
6 Clinical pharmacokinetics of tretinoin
7 13-cis retinoyl-beta-glucuronide in lacrimal gland fluid of rabbits treated with 13-cis retinoic acid

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