Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003004)
Formula
SVG example
Hydroxylation
Reactant Ergocalciferol Product 20-hydroxyvitamin D
Reactant Info Product Info
Metabolic Enzyme Cholesterol desmolase (CYP11A1) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002999 Ergocalciferol 20(OH)D2 Unclear - Unclear Ergocalciferol [1]
MR003002 Ergocalciferol 24(R),25dihydroxyvitamin D Unclear - Unclear Ergocalciferol [2]
MR002997 Ergocalciferol 25-hydroxyvitamin D Unclear - Unclear Ergocalciferol [2], [3], [4]
MR003003 Ergocalciferol Beta-ergocalciferol Unclear - Unclear Ergocalciferol [2]
References
1 The Metabolic Activation of Sofosbuvir Is Impaired in an Experimental Model of NAFLD. Biology (Basel). 2022 Apr 30;11(5):693. doi: 10.3390/biology11050693.
2 Vitamin D: mechanisms of action and clinical applications. Endocrinol Metab Clin North Am. 2017 Dec;46(4):xvii-xviii.
3 Characterization of rat and human CYP2J enzymes as Vitamin D 25-hydroxylases. Steroids. 2006 Oct;71(10):849-56.
4 CYP2R1 (vitamin D 25-hydroxylase) gene is associated with susceptibility to type 1 diabetes and vitamin D levels in Germans. Diabetes Metab Res Rev. 2007 Nov;23(8):631-6.

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