Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003006)
Formula Reactant Erlotinib M13 Product Erlotinib M2
Reactant Info Product Info
Metabolic Enzyme DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003005 Erlotinib hydrochloride Erlotinib M13 Oxidation - O-demethylation Erlotinib hydrochloride [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003012 Erlotinib M13 Erlotinib M11 Oxidation - Oxidation Erlotinib hydrochloride [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003007 Erlotinib M2 Erlotinib M14 Oxidation - O-demethylation Erlotinib hydrochloride [1], [2]
References
1 Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218.
2 Clinical pharmacokinetics of tyrosine kinase inhibitors. Cancer Treat Rev. 2009 Dec;35(8):692-706.

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