Details of the Metabolic Reaction (MR) | INTEDE

General Information of This Metabolic Reaction (MR) (ID: MR003101)
Formula
	Reactant	A77 1726		Product	Leflunomide metabolite M1
	Reactant	Reactant Info		Product	Product Info

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Produce The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR003102	Leflunomide	A77 1726	Oxidation - N-Dealkylation	Leflunomide	[1], [2]

References
1	In vitro metabolism of leflunomide by mouse and human liver microsomes Drug Metab Lett. 2007 Dec;1(4):299-305. doi: 10.2174/187231207783221402.
2	In vitro metabolism studies on the isoxazole ring scission in the anti-inflammatory agent lefluonomide to its active alpha-cyanoenol metabolite A771726: mechanistic similarities with the cytochrome P450-catalyzed dehydration of aldoximes Drug Metab Dispos. 2003 Oct;31(10):1240-50. doi: 10.1124/dmd.31.10.1240.

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