Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003104)
Formula
SVG example
Deamination
Reactant Leflunomide Product 5-Methylisoxazole carboxylic acid
Reactant Info Product Info
Metabolic Type Oxidation - Deamination
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003105 Leflunomide . Unclear Leflunomide [1]
MR003102 Leflunomide A77 1726 Oxidation - N-Dealkylation Leflunomide [2], [3]
MR003103 Leflunomide Trifluoromethylaniline Oxidation - Deamination Leflunomide [2]
References
1 Leflunomide-induced acute hepatitis. Dig Liver Dis. 2004 Jan;36(1):82-4.
2 In vitro metabolism of leflunomide by mouse and human liver microsomes Drug Metab Lett. 2007 Dec;1(4):299-305. doi: 10.2174/187231207783221402.
3 In vitro metabolism studies on the isoxazole ring scission in the anti-inflammatory agent lefluonomide to its active alpha-cyanoenol metabolite A771726: mechanistic similarities with the cytochrome P450-catalyzed dehydration of aldoximes Drug Metab Dispos. 2003 Oct;31(10):1240-50. doi: 10.1124/dmd.31.10.1240.

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