Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003112)
Formula
SVG example
Demethylation
Reactant NorLAAM Product Dinor-levomethadyl acetate
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008030 Levomethadyl Acetate Noracymethadol Oxidation - N-demethylation Levomethadyl Acetate [1]
MR003113 Levomethadyl acetate hydrochloride NorLAAM Oxidation - Demethylation Levomethadyl acetate hydrochloride [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008029 Nor-levomethadyl acetate (nor-LAAM) Dinor-levomethadyl acetate Unclear - Unclear Levomethadyl Acetate [4]
References
1 DrugBank(Pharmacology-Metabolism):Levomethadyl Acetate
2 Paradoxical role of cytochrome P450 3A in the bioactivation and clinical effects of levo-alpha-acetylmethadol: importance of clinical investigations to validate in vitro drug metabolism studies. Clin Pharmacokinet. 2005;44(7):731-51.
3 N-demethylation of levo-alpha-acetylmethadol by human placental aromatase. Biochem Pharmacol. 2004 Mar 1;67(5):885-92.
4 The KEGG resource for deciphering the genome

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