Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003199)
Formula
CYP3A4 ...
SVG example
N-Debenzylization
Reactant Barnidipine Product Barnidipine metabolite M-1
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 3A7 (CYP3A7) DME Info
Cytochrome P450 3A43 (CYP3A43) DME Info
Metabolic Type Oxidation - N-Debenzylization
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003200 Barnidipine Barnidipine metabolite M-8 Oxidation - Oxidation Barnidipine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003191 Barnidipine metabolite M-1 Barnidipine metabolite M-2 Unclear Barnidipine [1]
MR003190 Barnidipine metabolite M-1 Barnidipine metabolite M-3 Hydrolysis - Hydrolysis Barnidipine [1]
MR003192 Barnidipine metabolite M-1 Barnidipine metabolite M-7 Unclear Barnidipine [1]
References
1 Examination of metabolic pathways and identification of human liver cytochrome P450 isozymes responsible for the metabolism of barnidipine, a calcium channel blocker. Xenobiotica. 1997 Sep;27(9):885-900.

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