Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003204)
Formula
SVG example
Esterification
Reactant Desisobutyrylciclesonide Product C21-Lipid conjugation
Reactant Info Product Info
Metabolic Type Other reaction - Esterification
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003207 Ciclesonide Desisobutyrylciclesonide Hydrolysis - Hydrolysis Ciclesonide [1], [2], [3], [4]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003206 Desisobutyrylciclesonide Ciclesonide metabolite M2 Unclear Ciclesonide [5]
MR003205 Desisobutyrylciclesonide Ciclesonide metabolite M3 Unclear Ciclesonide [5]
References
1 Ciclesonide Drugs. 2004;64(5):511-9; discussion 520-1. doi: 10.2165/00003495-200464050-00005.
2 Deposition and metabolism of inhaled ciclesonide in the human lung Eur Respir J. 2010 Nov;36(5):1113-9. doi: 10.1183/09031936.00172309.
3 LC-HRMS/MS study of the prodrug ciclesonide and its active metabolite desisobutyryl-ciclesonide in plasma after an inhalative administration to horses for doping control purposes. Drug Test Anal. 2022 Feb;14(2):252-261. doi: 10.1002/dta.3174.
4 Visualizing the spatial localization of ciclesonide and its metabolites in rat lungs after inhalation of 1-m aerosol of ciclesonide by desorption electrospray ionization-time of flight mass spectrometry imaging. Int J Pharm. 2021 Feb 15;595:120241. doi: 10.1016/j.ijpharm.2021.120241.
5 In Vitro metabolism of ciclesonide in human lung and liver precision-cut tissue slices Biopharm Drug Dispos. 2006 May;27(4):197-207. doi: 10.1002/bdd.500.

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