Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003222)
Formula
UGT1A9 ...
SVG example
Oxidation
Reactant Darolutamide Product Ketodarolutamide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003230 Darolutamide Darolutamide metabolite M15a,15b Conjugation - Glucuronidation Darolutamide [1]
MR003228 Darolutamide Darolutamide metabolite M2 Conjugation - Glucuronidation Darolutamide [1]
MR003223 Darolutamide Darolutamide metabolite M31 Unclear Darolutamide [1]
MR003227 Darolutamide Darolutamide metabolite M32 Oxidation - N-Dealkylation Darolutamide [1]
MR003226 Darolutamide Darolutamide metabolite M33 Oxidation - N-Dealkylation Darolutamide [1]
MR003224 Darolutamide Darolutamide metabolite M34 Oxidation - N-Dealkylation Darolutamide [1]
MR003225 Darolutamide Darolutamide metabolite M36 Oxidation - N-Dealkylation Darolutamide [1]
MR003229 Darolutamide Darolutamide metabolite M7a,7b Conjugation - Glucuronidation Darolutamide [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003211 Ketodarolutamide Darolutamide metabolite M10 Conjugation - Glucuronidation Darolutamide [1]
MR003212 Ketodarolutamide Darolutamide metabolite M28 Unclear Darolutamide [1]
MR003210 Ketodarolutamide Darolutamide metabolite M31 Unclear Darolutamide [1]
MR003215 Ketodarolutamide Darolutamide metabolite M33 Oxidation - N-Dealkylation Darolutamide [1]
MR003213 Ketodarolutamide Darolutamide metabolite M34 Oxidation - N-Dealkylation Darolutamide [1]
MR003214 Ketodarolutamide Darolutamide metabolite M36 Oxidation - N-Dealkylation Darolutamide [1]
⏷ Show the Full List of MR
References
1 Metabolism and Mass Balance of the Novel Nonsteroidal Androgen Receptor Inhibitor Darolutamide in Humans Drug Metab Dispos. 2021 Jun;49(6):420-433. doi: 10.1124/dmd.120.000309.

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