Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003252)
Formula
CYP3A4 ...
SVG example
Reactant Delamanid Product (4RS,5S)-DM-6720
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 1A1 (CYP1A1) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 2E1 (CYP2E1) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003251 Delamanid DM-6705 Unclear Delamanid [1], [2], [3], [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003250 (4RS,5S)-DM-6720 (S)-DM-6718 Unclear Delamanid [1]
References
1 Pharmacokinetics and metabolism of delamanid, a novel anti-tuberculosis drug, in animals and humans: importance of albumin metabolism in vivo. Drug Metab Dispos. 2015 Aug;43(8):1267-76.
2 Liquid chromatography-tandem mass spectrometry analysis of delamanid and its metabolite in human cerebrospinal fluid using protein precipitation and on-line solid-phase extraction. J Pharm Biomed Anal. 2023 Apr 1;227:115281. doi: 10.1016/j.jpba.2023.115281.
3 Relative bioavailability of delamanid 50?mg tablets dispersed in water in healthy adult volunteers. Br J Clin Pharmacol. 2023 Jan 24. doi: 10.1111/bcp.15672.
4 Assessing Prolongation of the Corrected QT?Interval with Bedaquiline and Delamanid Coadministration to Predict the Cardiac Safety?of Simplified Dosing Regimens. Clin Pharmacol Ther. 2022 Oct;112(4):873-881. doi: 10.1002/cpt.2685.

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