Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003266)
Formula
UGT
SVG example
Glucuronidation
Reactant 2-hydroxynevirapine Product 2-hydroxynevirapine glucuronide metabolite
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronyltransferase (UGT) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003270 Nevirapine 2-hydroxynevirapine Oxidation - 2-Hydroxylation Nevirapine [1], [2]
References
1 Disposition and biotransformation of the antiretroviral drug nevirapine in humans Drug Metab Dispos. 1999 Aug;27(8):895-901.
2 Differences in nevirapine biotransformation as a factor for its sex-dependent dimorphic profile of adverse drug reactions J Antimicrob Chemother. 2014 Feb;69(2):476-82. doi: 10.1093/jac/dkt359.

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