Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003269)
Formula
CYP3A4 ...
SVG example
Hydroxylation
Reactant Nevirapine Product 12-hydroxynevirapine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003270 Nevirapine 2-hydroxynevirapine Oxidation - 2-Hydroxylation Nevirapine [1], [2]
MR003272 Nevirapine 3-hydroxynevirapine Oxidation - 3-Hydroxylation Nevirapine [3]
MR003271 Nevirapine 8-hydroxynevirapine Oxidation - 8-Hydroxylation Nevirapine [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003265 12-hydroxynevirapine 12-hydroxynevirapine glucuronide metabolite Unclear Nevirapine [2]
MR003263 12-hydroxynevirapine 12-sulphoxy-nevirapine Unclear Nevirapine [2]
MR003264 12-hydroxynevirapine 4-carboxynevirapine Unclear Nevirapine [2]
References
1 Disposition and biotransformation of the antiretroviral drug nevirapine in humans Drug Metab Dispos. 1999 Aug;27(8):895-901.
2 Differences in nevirapine biotransformation as a factor for its sex-dependent dimorphic profile of adverse drug reactions J Antimicrob Chemother. 2014 Feb;69(2):476-82. doi: 10.1093/jac/dkt359.
3 U. S. FDA Label -Nevirapine

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