Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003309)
Formula
UGT
SVG example
Glucuronidation
Reactant Dihydroxy ketobemidone Product N-Acetyl-5-hydroxytryptamine glucuronide metabolite
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronyltransferase (UGT) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001335 Ketobemidone Dihydroxy ketobemidone Unclear Ketobemidone [1]
MR003315 Melatonin Dihydroxy ketobemidone Oxidation - O-Demethylation Melatonin [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001331 Dihydroxy ketobemidone M-hydroxymethoxy ketobemidone Unclear Ketobemidone [1]
MR003310 Dihydroxy ketobemidone N-Acetyl-5-hydroxytryptamine sulfate metabolite Other reaction - Sulfonation Melatonin [1]
MR001330 Dihydroxy ketobemidone p-hydroxymethoxy ketobemidone Unclear Ketobemidone [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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