Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003325)
Formula Reactant Nimesulide metabolite M2 Product Nimesulide metabolite M3
Reactant Info Product Info
Metabolic Enzyme Prostaglandin G/H synthase 2 (COX-2) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003319 4-hydroxynimesulideM1 Nimesulide metabolite M2 Unclear Nimesulide [1]
MR003320 Nimesulide metabolite M5A,5B Nimesulide metabolite M2 Unclear Nimesulide [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003326 Nimesulide metabolite M3 Nimesulide metabolite M4 Unclear Nimesulide [1]
References
1 Neutrophil- and myeloperoxidase-mediated metabolism of reduced nimesulide: evidence for bioactivation Chem Res Toxicol. 2010 Nov 15;23(11):1691-700. doi: 10.1021/tx1001496.

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