Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003338)
Formula Reactant Safinamide mesylate Product Safinamide mesylate carboxylic acid
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003342 Safinamide mesylate O-debenzylated safinamide Oxidation - Dealkylation Safinamide mesylate [1], [2]
MR003341 Safinamide mesylate Safinamide acid Unclear Safinamide mesylate [1]
MR003340 Safinamide mesylate Safinamide mesylate Oxidation - Dealkylation Safinamide mesylate [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003339 Safinamide mesylate carboxylic acid Safinamide mesylate Glucuronidated metabolites Conjugation - Glucuronidation Safinamide mesylate [1]
References
1 Disposition and metabolism of safinamide, a novel drug for Parkinson's disease, in healthy male volunteers. Pharmacology. 2013;92(3-4):207-16.
2 DailyMed : Safinamide mesylate

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