Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003370)
Formula
SVG example
Reactant Diclofenac Product 4'-hydroxydiclofenac
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003372 Aceclofenac Diclofenac Hydrolysis - Hydrolysis Aceclofenac [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002613 Diclofenac sodium 4'-hydroxydiclofenac Oxidation - 4'-Hydroxylation Diclofenac sodium [2], [3], [4]
MR003369 4'-hydroxyaceclofenac 4'-hydroxydiclofenac Unclear Aceclofenac [5]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002602 4'-hydroxydiclofenac 4'-hydroxy-2'-glutathione conjugated monoclofenac Conjugation - Glutathione Conjugation Diclofenac sodium [2]
MR002603 4'-hydroxydiclofenac 4'-hydroxy-3'-glutathione conjugated diclofenac Conjugation - Glutathione Conjugation Diclofenac sodium [6]
References
1 Aceclofenac in the management of inflammatory pain Expert Opin Pharmacother. 2004 Jun;5(6):1347-57. doi: 10.1517/14656566.5.6.1347.
2 Clinical pharmacokinetics of diclofenac. Therapeutic insights and pitfalls Clin Pharmacokinet. 1997 Sep;33(3):184-213. doi: 10.2165/00003088-199733030-00003.
3 Plasma and synovial fluid concentrations of diclofenac sodium and its major hydroxylated metabolites during long-term treatment of rheumatoid arthritis Eur J Clin Pharmacol. 1983;25(3):389-94. doi: 10.1007/BF01037953.
4 Simultaneous determination of diclofenac sodium and its hydroxy metabolites by capillary column gas chromatography with electron-capture detection J Chromatogr. 1981 Nov 6;217:263-71. doi: 10.1016/s0021-9673(00)88081-4.
5 Modeling of aceclofenac metabolism to major metabolites in healthy volunteers Drug Metab Pharmacokinet. 2016 Dec;31(6):458-463. doi: 10.1016/j.dmpk.2016.10.001.
6 DrugBank(Pharmacology-Metabolism)Diclofenac sodium

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