Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003389)
Formula Reactant Naftopidil Product S-Naftopidil
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003388 Naftopidil R-Naftopidil Unclear Naftopidil [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003385 S-Naftopidil R-Naftopidil metabolite M1 Unclear Naftopidil [2], [3]
MR003386 S-Naftopidil R-Naftopidil metabolite M2 Unclear Naftopidil [2], [3]
MR003387 S-Naftopidil R-Naftopidil metabolite M3 Unclear Naftopidil [2], [3]
References
1 U. S. FDA Label -Naftopidil
2 Identification of human cytochrome P450 isozymes involved in the metabolism of naftopidil enantiomers in vitro. J Pharm Pharmacol. 2014 Nov;66(11):1534-51.
3 Characterization of Ca(2+)-antagonistic effects of three metabolites of the new antihypertensive agent naftopidil, (naphthyl)hydroxy-naftopidil, (phenyl)hydroxy-naftopidil, and O-desmethyl-naftopidil J Cardiovasc Pharmacol. 1991 Dec;18(6):918-25. doi: 10.1097/00005344-199112000-00020.

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