Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003393)
Formula
SVG example
Oxidation
Reactant Febuxostat metabolite 67M-1 Product Febuxostat metabolite 67M-4(di-carboxylic acid)
Reactant Info Product Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003399 Febuxostat Febuxostat metabolite 67M-1 Oxidation - Oxidation Febuxostat [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003394 Febuxostat metabolite 67M-1 Febuxostat metabolite 67M-1 sulfate conjugate Conjugation - Conjugation Febuxostat [2]
MR003396 Febuxostat metabolite 67M-1 Febuxostat metabolite 7M-1 glucuronide Conjugation - Conjugation Febuxostat [2]
MR003395 Febuxostat metabolite 67M-1 Febuxostat metabolite Dehydrated 67M-1 glucuronide Other reaction - Dehydration Febuxostat [2]
References
1 In vitro drug-drug interaction studies with febuxostat, a novel non-purine selective inhibitor of xanthine oxidase: plasma protein binding, identification of metabolic enzymes and cytochrome P450 inhibition. Xenobiotica. 2008 May;38(5):496-510.
2 Metabolism and excretion of [14C] febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase, in healthy male subjects J Clin Pharmacol. 2011 Feb;51(2):189-201. doi: 10.1177/0091270010365549.

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