Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003492)
Formula Reactant Valdecoxib metabolite M9 Product Valdecoxib metabolite M3
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003303 Valdecoxib Valdecoxib metabolite M9 Oxidation - Hydroxylation Valdecoxib [1]
MR003491 Valdecoxib Valdecoxib metabolite M9 Oxidation - Hydroxylation Parecoxib [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003300 Valdecoxib metabolite M9 Valdecoxib metabolite M9-G Unclear Valdecoxib [1]
MR003493 Valdecoxib metabolite M9 Valdecoxib metabolite M9-G Unclear Parecoxib [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003294 Valdecoxib metabolite M1 Valdecoxib metabolite M3 Oxidation - Hydroxylation Valdecoxib [1]
MR003487 Valdecoxib metabolite M1 Valdecoxib metabolite M3 Oxidation - Hydroxylation Parecoxib [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003297 Valdecoxib metabolite M3 Valdecoxib metabolite M3-G Oxidation - S-Oxidation Valdecoxib [1]
MR014140 Valdecoxib metabolite M3 Valdecoxib metabolite M3-G Oxidation - S-Oxidation Parecoxib [1]
References
1 Disposition of a specific cyclooxygenase-2 inhibitor, valdecoxib, in human Drug Metab Dispos. 2002 Sep;30(9):1013-21. doi: 10.1124/dmd.30.9.1013.
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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