Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003500)
Formula Reactant 9-O-demethylemetine Product 9-O-demethylemetine glucuronide metabolite
Reactant Info Product Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003499 Ipecac 9-O-demethylemetine Oxidation - Demethylation Ipecac [1], [2]
MR006986 Q-100155 9-O-demethylemetine Oxidation - Demethylation Q-100155 [3]
References
1 Metabolism of ipecac alkaloids cephaeline and emetine by human hepatic microsomal cytochrome P450s, and their inhibitory effects on P450 enzyme activities. Biol Pharm Bull. 2001 Jun;24(6):678-82.
2 Biotransformation of the ipecac alkaloids cephaeline and emetine from ipecac syrup in rats Eur J Drug Metab Pharmacokinet. 2002 Jan-Mar;27(1):29-35. doi: 10.1007/BF03190402.
3 Poncirin and its metabolite ponciretin attenuate colitis in mice by inhibiting LPS binding on TLR4 of macrophages and correcting Th17/Treg imbalance

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