Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003525)
Formula
FMO1 ...
SVG example
N-Oxidation
Reactant Tamoxifen citrate Product Tamoxifen N-oxide
Reactant Info Product Info
Metabolic Enzyme Dimethylaniline oxidase 1 (FMO1) DME Info
Dimethylaniline oxidase 3 (FMO3) DME Info
Metabolic Type Oxidation - N-Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003526 Tamoxifen citrate 4-hydroxytamoxifen Oxidation - 4-Hydroxylation Tamoxifen citrate [1], [2], [3], [4]
MR003522 Tamoxifen citrate Alpha-hydroxytamoxifen Oxidation - Hydroxylation Tamoxifen citrate [5], [4]
MR003510 Tamoxifen citrate N-Desmethyltamoxifen Oxidation - N-Dealkylation Tamoxifen citrate [1], [2], [3], [6], [7]
References
1 Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen. Drug Metab Dispos. 2002 Aug;30(8):869-74.
2 Endoxifen and other metabolites of tamoxifen inhibit human hydroxysteroid sulfotransferase 2A1 (hSULT2A1). Drug Metab Dispos. 2014 Nov;42(11):1843-50.
3 Metabolism and transport of tamoxifen in relation to its effectiveness: new perspectives on an ongoing controversy. Future Oncol. 2014 Jan;10(1):107-22.
4 The tamoxifen dilemma. Carcinogenesis. 1999 Jul;20(7):1153-60.
5 [Effect of lithium on the hematopoietic stem cells] Acta Haematol Pol. 1989 Jan-Jun;20(1):99-106.
6 Identification and biological activity of tamoxifen metabolites in human serum Biochem Pharmacol. 1983 Jul 1;32(13):2045-52. doi: 10.1016/0006-2952(83)90425-2.
7 PharmGKB summary: tamoxifen pathway, pharmacokinetics Pharmacogenet Genomics. 2013 Nov;23(11):643-7. doi: 10.1097/FPC.0b013e3283656bc1.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.