Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003608)
Formula Reactant Cibenzoline Product Cibenzoline Metabolite M3
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003610 Cibenzoline 2-(2,2-diphenylcyclopropyl)-1H-imidazole Unclear Cibenzoline [1]
MR003607 Cibenzoline 4,5-dehydrocibenzoline Oxidation - Hydrolyzationn Cibenzoline [2]
MR003609 Cibenzoline Cibenzoline Metabolite M4 Oxidation - Hydrolyzationn Cibenzoline [2]
MR003606 Cibenzoline p-hydroxycibenzoline Oxidation - Hydrolyzationn Cibenzoline [2]
References
1 Biotransformation of cibenzoline to 2-(2,2-diphenylcyclopropyl)-1H-imidazole
2 Stereoselective metabolism of cibenzoline, an antiarrhythmic drug, by human and rat liver microsomes: possible involvement of CYP2D and CYP3A. Drug Metab Dispos. 2000 Sep;28(9):1128-34.

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