Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003703)
Formula
SVG example
N-Dealkylation
Reactant LAS-X-113 Product Desalkylebastine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-Dealkylation
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009229 Ebastine Deslakylebastine Oxidation - N-dealkylation Ebastine [1]
MR009221 Carebastine Deslakylebastine Oxidation - N-dealkylation Ebastine [2]
References
1 Involvement of CYP2J2 and CYP4F12 in the metabolism of ebastine in human intestinal microsomes
2 Characterization of ebastine, hydroxyebastine, and carebastine metabolism by human liver microsomes and expressed cytochrome P450 enzymes: major roles for CYP2J2 and CYP3A. Drug Metab Dispos. 2006 Nov;34(11):1793-7.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.