Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003954)
Formula Reactant MK-0822 Metabolite M8 (Odanacatib) Product MK-0822 Metabolite M7-B (Odanacatib)
Reactant Info Product Info
Metabolic Type Oxidation - Oxidationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003953 MK-0822 MK-0822 Metabolite M8 (Odanacatib) Oxidation - Hydrolyzationn MK-0822 [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003957 MK-0822 Metabolite M8 (Odanacatib) MK-0822 Metabolite M2-A Unclear MK-0822 [2]
MR003956 MK-0822 Metabolite M8 (Odanacatib) MK-0822 Metabolite M3 (Odanacatib) Conjugation - Glucuronidation MK-0822 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003955 MK-0822 Metabolite M7-B (Odanacatib) MK-0822 Metabolite M7-A (Odanacatib) Other reaction - Cyclization MK-0822 [1]
References
1 Disposition and metabolism of the cathepsin K inhibitor odanacatib in humans. Drug Metab Dispos. 2014 May;42(5):818-27.
2 Pharmacokinetics and metabolism in rats, dogs, and monkeys of the cathepsin k inhibitor odanacatib: demethylation of a methylsulfonyl moiety as a major metabolic pathway

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