Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004043)
Formula Reactant SQ-109 Product SQ-109 Metabolite M2-1
Reactant Info Product Info
Metabolic Enzyme Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - Ring oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004038 SQ-109 M/Z 347 Oxidation - Epoxidation SQ-109 [1]
MR004040 SQ-109 SQ-109 Metabolite M1 Oxidation - N-Nitrosylation SQ-109 [1]
MR004041 SQ-109 SQ-109 Metabolite M3 Oxidation - N-Nitrosylation SQ-109 [1]
MR004042 SQ-109 SQ-109 Metabolite M4 Oxidation - N-Dealkylation SQ-109 [1]
MR004045 SQ-109 SQ-109 Metabolite M4-1 Oxidation - Ring oxidation; N-hydroxylation SQ-109 [1]
MR004044 SQ-109 SQ-109 Metabolite M4-2 Multi-steps Reaction - Ring oxidation; Epoxidation; rearrangement SQ-109 [1]
References
1 Interspecies pharmacokinetics and in vitro metabolism of SQ109. Br J Pharmacol. 2006 Mar;147(5):476-85.

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