Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004113)
Formula
SVG example
Ring cleavage; Dealkylation
Reactant Copanlisib Product Copanlisib metabolite M455
Reactant Info Product Info
Metabolic Type Multi-steps Reaction - Ring cleavage; Dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004114 Copanlisib Copanlisib metabolite M483a Reduction - Reduction Copanlisib [1]
MR004115 Copanlisib Copanlisib metabolite M483b Multi-steps Reaction - Morpholine ring cleavage; Dealkylation Copanlisib [1]
MR004112 Copanlisib Copanlisib metabolite M495 Oxidation - Alpha-Oxidationn Copanlisib [1]
MR004110 Copanlisib Copanlisib metabolite M497a Oxidation - Hydrolyzationn Copanlisib [1]
MR004111 Copanlisib Copanlisib metabolite M497b Oxidation - Alpha-Hydrolyzationn Copanlisib [1]
MR004116 Copanlisib Copanlisib metabolite M499 Multi-steps Reaction - Reduction; N-oxidation Copanlisib [1]
References
1 Reactive intermediates in copanlisib metabolism identified by LC-MS/MS: phase I metabolic profiling

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