Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004122)
Formula Reactant Crizotinib Product Crizotinib metabolite M4
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004117 Crizotinib Crizotinib metabolite M10 Unclear Crizotinib [1]
MR004127 Crizotinib PF-06260182 Oxidation - Oxidationn Crizotinib [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004126 Crizotinib metabolite M4 Crizotinib metabolite M1 Unclear Crizotinib [1]
MR004123 Crizotinib metabolite M4 Crizotinib metabolite M2 Unclear Crizotinib [1]
MR004124 Crizotinib metabolite M4 Crizotinib metabolite M3 Unclear Crizotinib [1]
MR004125 Crizotinib metabolite M4 Crizotinib metabolite M5 Multi-steps Reaction - Hydrolyzationn; Glucuronidation Crizotinib [1]
References
1 Metabolism, excretion and pharmacokinetics of [14C]crizotinib following oral administration to healthy subjects
2 DrugBank(Pharmacology-Metabolism):Crizotinib

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