Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004332)
Formula
SVG example
Hydrogenation
Reactant Naringenin Product Apigenin
Reactant Info Product Info
Metabolic Type Reduction - Hydrogenation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003855 BRN-0183227 Naringenin Oxidation - Hydrolyzationn BRN-0183227 [1]
MR006956 CCG-208408 Naringenin Unclear CCG-208408 [2]
MR004309 Naringin Naringenin Hydrolysis - Hydrolyzation Naringin [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006957 Naringenin 3-(4-Hydroxyphenyl)propionic acid Unclear CCG-208408 [2]
MR004322 Naringenin 4'-O-Methyl-naringenin Conjugation - Methylationn Naringin [3]
MR004331 Naringenin 5,7-Dihydroxyflavanone Reduction - Dehydroxylation Naringin [3]
MR004316 Naringenin 6-Hydroxyl-naringenin Oxidation - Hydrolyzationn Naringin [3]
MR004318 Naringenin 8-Hydroxyl-naringeni Oxidation - Hydrolyzationn Naringin [3]
MR004320 Naringenin Eriodictyol Oxidation - Hydrolyzationn Naringin [3]
MR003856 Naringenin Isosakuranetin Unclear BRN-0183227 [1]
MR003859 Naringenin Naringenin-4',7-sulfo-O-glucuronide Unclear BRN-0183227 [4]
MR004330 Naringenin Naringenin-4'-O-glucoside Conjugation - Glucosylation Naringin [3]
MR003860 Naringenin Naringenin-4'-O-glucuronide Unclear BRN-0183227 [4]
MR004329 Naringenin Naringenin-5-O-glucoside Conjugation - Glucosylation Naringin [3]
MR003861 Naringenin Naringenin-7-O-glucuronide Unclear BRN-0183227 [4]
MR004310 Naringenin p-Coumaric acid Other reaction - Ring cleavage reaction Naringin [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003841 BE-14348A Apigenin Oxidation - Dehydrogenation BE-14348A [5]
References
1 Flavanone metabolism in healthy and tumor-bearing rats
2 Catabolism of citrus flavanones by the probiotics Bifidobacterium longum and Lactobacillus rhamnosus. Eur J Nutr. 2018 Feb;57(1):231-242.
3 Microbial Metabolism of Naringin and the Impact on Antioxidant Capacity
4 Stratification of Volunteers According to Flavanone Metabolite Excretion and Phase II Metabolism Profile after Single Doses of 'Pera' Orange and 'Moro' Blood Orange Juices
5 Pharmacokinetics and Metabolism of Naringin and Active Metabolite Naringenin in Rats, Dogs, Humans, and the Differences Between Species

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