Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004427)
Formula
SVG example
Reactant Oxazepam Product Oxazepam glucuronides
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002863 Oxazepam . Oxidation - Deamination Oxazepam [1]
MR002862 Oxazepam Oxazepam glucuronide Conjugation - O-Glucuronidation Oxazepam [2]
MR002379 Oxazepam Temazepam metabolite M1 Conjugation - Conjugation Temazepam [3]
MR002109 Oxazepam 4'-hydroxyoxazepam Oxidation - Hydroxylation Prazepam [4], [5]
MR002108 Oxazepam Oxazepam glucuronide Conjugation - Glucuronidation Prazepam [4], [5]
References
1 Cytochrome P450 enzyme activity and protein expression in primary porcine enterocyte and hepatocyte cultures. Xenobiotica. 2000 Jan;30(1):27-46.
2 Stereoselective conjugation of oxazepam by human UDP-glucuronosyltransferases (UGTs): S-oxazepam is glucuronidated by UGT2B15, while R-oxazepam is glucuronidated by UGT2B7 and UGT1A9. Drug Metab Dispos. 2002 Nov;30(11):1257-65.
3 Pharmacokinetics and metabolism of temazepam in man and several animal species Br J Clin Pharmacol. 1979;8(1):23S-29S. doi: 10.1111/j.1365-2125.1979.tb00451.x.
4 Prazepam metabolism by man Clin Pharmacol Ther. 1970 Nov-Dec;11(6):890-7. doi: 10.1002/cpt1970116890.
5 Prazepam metabolites in dog urine J Pharm Sci. 1970 Mar;59(3):322-5. doi: 10.1002/jps.2600590309.

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