Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004626)
Formula Reactant Desipramine Product 2-OH-desipramine
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002595 Desipramine 2-hydroxydesipramine Oxidation - 2-Hydroxylation Desipramine [1]
MR012987 Desipramine 2-hydroxydesipramine Oxidation - Hydrolyzationn Imipramine hydrochloride [2]
References
1 Clinical pharmacokinetics of imipramine and desipramine
2 The Use of In Vitro Data and Physiologically-Based Pharmacokinetic Modeling to Predict Drug Metabolite Exposure: Desipramine Exposure in Cytochrome P4502D6 Extensive and Poor Metabolizers Following Administration of Imipramine

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