Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004628)
Formula
	Reactant	Imipramine oxide	Product	Desipramine
	Reactant	Reactant Info	Product	Product Info

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR004624	Imipramine oxide	Imipramine	Unclear	Imipramine oxide	[1]

Other MR(s) Related to The Product of This MR

Other MR(s) That Produce The Product of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR012986	Imipramine hydrochloride	Desipramine	Oxidation - N-demethylation	Imipramine hydrochloride	[2]
MR004625	Imipramine	Desipramine	Unclear	Imipramine oxide	[1], [3]

References
1	Imipramine metabolites in blood of patients during therapy and after overdose
2	Eight inhibitory monoclonal antibodies define the role of individual P-450s in human liver microsomal diazepam, 7-ethoxycoumarin, and imipramine metabolism. Drug Metab Dispos. 1999 Jan;27(1):102-9.
3	Deletion of the mouse Fmo1 gene results in enhanced pharmacological behavioural responses to imipramine

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