Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004735)
Formula
CYP1A2 ...
SVG example
2-hydroxylation
Reactant Mexiletine hydrochloride Product 2-hydroxymexiletine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - 2-hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004739 Mexiletine hydrochloride M-hydroxy ME Unclear Mexiletine hydrochloride [1]
MR004737 Mexiletine hydrochloride p-hydroxymexiletine Oxidation - Hydrolyzationn Mexiletine hydrochloride [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004736 2-hydroxymexiletine Deamino HMME Unclear Mexiletine hydrochloride [3]
References
1 [Thyroid neoplasms and HL-A system]
2 Involvement of CYP1A2 in mexiletine metabolism. Br J Clin Pharmacol. 1998 Jul;46(1):55-62.
3 Inhibition kinetics of theophylline metabolism by mexiletine and its metabolites

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