Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004743)
Formula
SVG example
Reactant 4-hydroxymidazolam Product 1',4'-dihydroxymidazolam
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004742 Midazolam hydrochloride 4-hydroxymidazolam Oxidation - 4-hydroxylation Midazolam hydrochloride [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004747 Midazolam hydrochloride 1',4'-dihydroxymidazolam Unclear Midazolam hydrochloride [2]
References
1 Heterotropic activation of the midazolam hydroxylase activity of CYP3A by a positive allosteric modulator of mGlu5: in vitro to in vivo translation and potential impact on clinically relevant drug-drug interactions
2 Pharmacokinetics and metabolism of midazolam in chimeric mice with humanised livers

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.