Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004786)
Formula
SVG example
N-demethylation
Reactant Mirtazapine Product N-desmethylmirtazapine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A (CYP3A) DME Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004787 Mirtazapine 8-hydroxymirtazapine Oxidation - 8-hydroxylation Mirtazapine [1]
MR004788 Mirtazapine Dimetilmirtazapine (DMR) Unclear Mirtazapine [2]
MR004785 Mirtazapine Mirtazapine-N-oxide Oxidation - N-oxidation Mirtazapine [3]
References
1 Clinical pharmacokinetics of mirtazapine
2 Pharmacokinetics of mirtazapine and its main metabolites in Beagle dogs: a pilot study
3 FDA label:Mirtazapine

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