Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004822)
Formula
SVG example
Glucuronidation
Reactant Mycophenolic acid Product Mycophenolic acid-acyl glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004823 Mycophenolic acid 6-O-desmethyl-mycophenolic acid Oxidation - Demethylation Mycophenolic acid [1], [2]
MR004824 Mycophenolic acid Mycophenolic acid glucuronide Conjugation - O-glucuronidation Mycophenolic acid [1], [3]
MR004812 Mycophenolic acid 6-O-desmethyl-MPA (DM-MPA) Unclear Mycophenolate mofetil [4]
MR004814 Mycophenolic acid 7-O-MPA glucoside Unclear Mycophenolate mofetil [4]
References
1 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
2 Characterization of a phase 1 metabolite of mycophenolic acid produced by CYP3A4/5. Ther Drug Monit. 2004 Dec;26(6):600-8.
3 The main role of UGT1A9 in the hepatic metabolism of mycophenolic acid and the effects of naturally occurring variants
4 DrugBank(Pharmacology-Metabolism):Mycophenolate mofetil

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