Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004880)
Formula
SVG example
Oxidationn
Reactant Nateglinide Product Nateglinide metabolite M7
Reactant Info Product Info
Metabolic Type Oxidation - Oxidationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004883 Nateglinide 2-{[4-(1-hydroxypropan-2-yl)cyclohexyl]formamido}-3-phenylpropanoic acid Oxidation - Aliphatic hydroxylation Nateglinide [1]
MR004884 Nateglinide 2-{[4-(2-hydroxypropan-2-yl)cyclohexyl]formamido}-3-phenylpropanoic acid Oxidation - Aliphatic hydroxylation Nateglinide [1]
MR004882 Nateglinide Nateglinide glucuronide and isomers (M4/M5/M6) Conjugation - Glucuronidation Nateglinide [1]
MR004878 Nateglinide Nateglinide metabolite M1 Oxidation - Hydrolyzationn Nateglinide [1]
MR004876 Nateglinide Nateglinide metabolite M2/M3 Oxidation - Hydrolyzationn Nateglinide [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004881 Nateglinide metabolite M7 Nateglinide metabolite M11/M12 Oxidation - Hydrolyzationn Nateglinide [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Pharmacokinetics of nateglinide enantiomers and their metabolites in Goto-Kakizaki rats, a model for type 2 diabetes mellitus

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