Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005017)
Formula
SVG example
Glucuronidation
Reactant Norfluoxetine Product Norfluoxetine glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 2A1 (UGT2A1) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005012 Fluoxetine hydrochloride Norfluoxetine Oxidation - N-demethylation Fluoxetine hydrochloride [1], [2], [3], [4]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005013 Norfluoxetine 4-Trifluoromethylphenol Oxidation - O-dealkylation Fluoxetine hydrochloride [5]
MR005015 Norfluoxetine Norfluoxetine alcohol Oxidation - Oxidationn deamination Fluoxetine hydrochloride [2]
References
1 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
3 (R)-, (S)-, and racemic fluoxetine N-demethylation by human cytochrome P450 enzymes. Drug Metab Dispos. 2000 Oct;28(10):1187-91.
4 Simultaneous identification and quantitation of fluoxetine and its metabolite, norfluoxetine, in biological samples by GC-MS
5 DrugBank(Pharmacology-Metabolism):Fluoxetine hydrochloride

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.